Chromosomal abnormalities predisposing to infertility, testing, and management: a narrative review

Abstract Background Much interest has not been placed on the role of chromosomal abnormalities in pathogenesis and rising prevalence infertility recent times. This review was conducted to renew public basis infertility, testing, management. Main text Meiotic post-zygotic mitotic errors may cause infertility-predisposing abnormalities, including Klinefelter syndrome, Jacob Triple X Turner Down syndrome. Chromosomal such as deletion, translocation, duplication, inversion, ring chromosome also predispose infertility. Notable features male include spermatogenic failure, characterized by azoospermia, oligospermia, gonadal dysgenesis, while females premature ovarian insufficiency, amenorrhea, spontaneous abortion, dysgenesis. The risk these is influenced maternal age environmental factors chemical exposure, smoking, alcohol consumption. Most occur spontaneously are treatable. However, early prenatal screening diagnostic tests can lessen effects conditions. There a growing belief that certain diets drugs capable changing gene expressions be formulated neutralize abnormalities. Conclusion during gametogenesis fetal development, respectively, which Couples who at increased risk, particularly those with family history women an advanced (? 35 years), should seek medical advice before getting pregnant.